Male patient being injected with Botox

The Surprising Sexual Health Benefit of Botox

Posted on May 16, 2016 by Dr Elenora Fedoneko

Botox has uses far beyond wrinkle eradication. That includes important sexual health benefits – and it’s not simply making users more sexually attractive. Surprisingly Botox injections may help men and women diagnosed with certain sexual dysfunctions.

Premature Ejaculation 

Premature ejaculation is the most common type of sexual dysfunction in men, affecting approximately 30 percent of all males. Unlike numerous medications approved by the FDA to treat erectile dysfunction, there is no approved drug for premature ejaculation. A Botox study conducted on rats provides hope for an eventual treatment in human males.

Bulbospongiosus Muscle

In both rats and men, the bulbospongiosus muscle in the penis controls ejaculation. The study involved 33 “sexually experienced” male rats. Prior to receiving Botox or a placebo, researchers studied rats’s sexual behavior. The male rats were then anesthetized and divided into groups receiving either:

  • O.5 units of Botox
  • 1 unit of Botox
  • Saline solution.

The injections were made directly into the bulbospongiosus muscle. Two days later, researchers again began examining animals sexual behaviors. The saline solution did not affect how long it took rats to ejaculate, but rats receiving either dose of Botox took much longer to do so. Rats receiving Botox did not experience any issues with sexual performance.

Clinical Trials 

The U.S. National Institutes of Health is currently recruiting men suffering from premature ejaculation for clinical trials involving Botox. Men with the condition ranging in age from 18 to 50 are eligible for the study. It will be conducted as a double-blind study, with one group receiving Botox injections and the other a saline solution. Criteria include:

  • Premature ejaculation history
  • Stable, monogamous relationship of at least six months duration with a female partner
  • Ability to follow instructions and complete assessments.

Men who have previously undergone Botox therapy for urological conditions are ineligible.


Vaginismus occurs when vaginal muscles involuntarily spasm, rendering penetration difficult or impossible. Small, experimental studies with affected women have been promising. Which muscles within the vagina cause the spasm is still not clear, so Botox is injected directly into the vaginal canal’s walls. Treatment with Botox reduces chronic muscle contractions.

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